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Updated: Apr 28, 2026
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
Published on: March 5, 2022
Elucidating the host-pathogen interaction between human colorectal cells and invading Enterovirus 71 using
Yan Long Edmund Lui1, Tuan Lin Tan2, Peter Timms3
1School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Queensland, Australia ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia ; School of Chemical and Life Sciences, Singapore Polytechnic, Singapore ; Centre for Biomedical and Life Sciences, Singapore Polytechnic, Singapore.
Abstract:
Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD) and has been shown to be associated with severe clinical manifestation. Currently, there is no antiviral therapeutic for the treatment of HFMD patients owing to a lack of understanding of EV71 pathogenesis. This study seeks to elucidate the transcriptomic changes that result from EV71 infection. Human whole genome microarray was employed to monitor changes in genomic profiles between infected and uninfected cells. The results reveal altered expression of human genes involved in critical pathways including the immune response and the stress response. Together, data from this study provide valuable insights into the host-pathogen interaction between human colorectal cells and EV71.
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