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Human Virome

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...

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Related Experiment Video

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High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Elucidating the host-pathogen interaction between human colorectal cells and invading Enterovirus 71 using

Yan Long Edmund Lui¹, Tuan Lin Tan², Peter Timms³

¹School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Queensland, Australia ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia ; School of Chemical and Life Sciences, Singapore Polytechnic, Singapore ; Centre for Biomedical and Life Sciences, Singapore Polytechnic, Singapore.

|June 12, 2014

Summary

This summary is machine-generated.

Enterovirus 71 (EV71) causes severe Hand, Foot, and Mouth Disease (HFMD). This study reveals EV71 infection alters human gene expression in immune and stress responses, offering insights into host-pathogen interactions.

Keywords:

Colorectal cells EV71, Enterovirus 71 Enterovirus 71 HFMD, Hand, Foot and Mouth Disease Hand, Foot and Mouth Disease ISG, interferon stimulated genes MOI, multiplicity of infection Microarray RD, rhabdomyosarcoma Transcriptomics mRNA profiling

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Published on: September 10, 2021

Area of Science:

Virology
Genomics
Immunology

Background:

Enterovirus 71 (EV71) is a primary cause of Hand, Foot, and Mouth Disease (HFMD), often leading to severe clinical outcomes.
Current treatment options for HFMD are limited due to an incomplete understanding of EV71 pathogenesis.

Purpose of the Study:

To investigate the transcriptomic alterations in human cells following EV71 infection.
To identify key host genes and pathways affected by EV71.

Main Methods:

Human whole genome microarray analysis was utilized.
Gene expression profiles of EV71-infected human colorectal cells were compared to uninfected controls.

Main Results:

EV71 infection significantly altered the expression of numerous human genes.
Affected genes were primarily involved in critical biological pathways, including immune response and stress response.
The study identified specific transcriptomic changes indicative of host-pathogen interactions.

Conclusions:

This research provides valuable insights into the molecular mechanisms underlying EV71 pathogenesis.
Understanding these transcriptomic changes is crucial for developing potential antiviral therapies for HFMD.
The findings highlight the complex interplay between EV71 and human host cells.