Related Experiment Video
Updated: Apr 28, 2026

Author Spotlight: Enhancing Success of Ultrasound-Guided Neuraxial Anesthesia in Cases with Difficult Anatomy
Published on: January 31, 2025
Subparaneural versus circumferential extraneural injection at the bifurcation level in ultrasound-guided popliteal
Olivier Choquet1, Guillaume Brault Noble, Bertrand Abbal
1From the *Department of Anesthesiology and Critical Care, Montpellier University Hospital; †Department of Anesthesiology and Critical Care Medicine, Lapeyronie University Hospital; ‡Epidemiology and Clinical Research Department, Arnaud de Villeneuve University Hospital; and §Institut National de la Sante et de la Recherche Médicale U1046, UM1, Montpellier, France.
Background:
The ideal spread of local anesthetic for effective, rapid, and safe sciatic nerve block is debated. We hypothesized that subparaneural ultrasound-guided injection results in faster onset and has a better success rate than extraneural circumferential spread.
Methods:
Patients undergoing elective tibial, foot, and ankle surgery with popliteal sciatic nerve blocks were prospectively enrolled. After randomization, the needle tip position was adjusted to ensure circumferential extraneural or subparaneural spread; 0.3 mL/kg of mepivacaine 10 mg/mL was injected. Post hoc video analysis was used to group the patients according to extraneural, subparaneural, and unintentional intraepineural spread.
Results:
There were 26 (43.3%) patients in the subparaneural group and 22 (36.7%) in the extraneural group. Block onset time was shorter in the subparaneural group than in the extraneural group (11 [3-21] minutes; mean [95% confidence interval], 11 [8.97-13.02] minutes and 17 [6-30] minutes; mean [95% confidence interval] 18.37 [14.17-22.57] minutes, respectively; P = 0.002). The duration of sensory blockade increased (397 [178-505] minutes vs 265 [113-525] minutes; P = 0.04). The success rate of the block also increased. Unintentional intraepineural injection occurred in 8% of patients (3 patients in the subparaneural group and 1 patient in the extraneural group; NS). Block onset time was shorter than for the subparaneural and extraneural groups (6 [3-12] minutes, 12 [3-21] minutes, and 18 [6-30] minutes; P = 0.01).
Conclusions:
A subparaneural injection accelerated the onset time and increased the duration of tibial nerve sensory blockade compared with circumferential extraneural injection. With unintentional intraepineural spread, the onset time was significantly shorter than for the other groups.
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Sites for measuring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Differential Sensitivity of Nerve Fibers

