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Related Experiment Videos

Tarsius delta- and beta-globin genes: conversions, evolution, and systematic implications.

B F Koop1, D Siemieniak, J L Slightom

  • 1Department of Molecular Biology and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201.

The Journal of Biological Chemistry
|January 5, 1989
PubMed
Summary
This summary is machine-generated.

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Gene conversions shape multigene family evolution. In primates, delta- and beta-globin gene conversions are less frequent and more localized than gamma-globin gene conversions, reflecting evolutionary constraints.

Area of Science:

  • Evolutionary biology
  • Genomics
  • Molecular evolution

Background:

  • Gene conversions are crucial for multigene family evolution.
  • Previous studies documented extensive conversions in gamma-fetal globin genes of catarrhine primates.

Purpose of the Study:

  • To investigate gene conversion patterns in delta- and beta-globin genes of primates.
  • To compare conversion events between delta-beta and gamma-globin gene families.
  • To understand the influence of conserved sequences on gene conversion frequency and extent.

Main Methods:

  • Isolation and sequencing of delta- and beta-globin genes from Tarsius syrichta and Pongo pygmaeus.
  • Comparative sequence analysis with other primate globin genes.
  • Phylogenetic analysis to infer evolutionary relationships.

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Main Results:

  • Confirmed a previously reported conversion in an anthropoid ancestor.
  • Identified new conversions in basal primate, stem haplorhine, tarsier, and early lemur lineages.
  • Delta-beta globin gene conversions are less frequent and restricted to coding and regulatory regions compared to gamma-globin genes.
  • Sequence divergence limits conversion frequency and size over time, with conserved regions undergoing conversion longer.

Conclusions:

  • Gene conversion patterns differ significantly between globin gene families.
  • Early duplications involve frequent, large-scale conversions, which become less frequent and more localized as sequences diverge.
  • Conserved sequences remain targets for gene conversion for extended evolutionary periods.
  • Sequence data supports the placement of tarsiers within the anthropoids.