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Liver regeneration with l-glutamine supplemented diet: experimental study in rats
Cibelle Ribeiro Magalhães1, Osvaldo Malafaia1, Orlando Jorge Martins Torres2
1Medical Research Institute, Evangelical Faculty of Paraná, Evangelical University Hospital.
Objective:
To assess liver regeneration in rats after 60% hepatectomy with and without supplementation of L-glutamine through liver weight changes, laboratory parameters and histological study.
Methods:
36 male rats were divided into two groups: glutamine group and control group. Each group was subdivided into three subgroups, with death in 24h, 72h and seven days. The glutamine group received water and standard diet supplemented with L-glutamine, and the control recieved 0.9% saline. In all subgroups analysis of liver regeneration was made by the Kwon formula, study of liver function (AST, ALT, GGT, total bilirubin, indirect and indirect bilirubin and albumin) and analysis of cell mitosis by hematoxylin-eosin.
Results:
In both groups there was liver regeneration by weight gain. Gamma-GT increased significantly in the control group (p < 0.05); albumin increased in the glutamine group. The other indicators of liver function showed no significant differences. Histological analysis at 72h showed a higher number of mitoses in the glutamine group, with no differences in other subgroups.
Conclusion:
Diet supplementation with L glutamine is beneficial for liver regeneration.
