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Point and Interval Estimators of the Target Dose in Clinical Dose-Finding Studies with Active Control

H-J Helms1, N Benda, T Friede

  • 1a Department of Medical Statistics , University Medical Center Göttingen , Humboldtallee , Göttingen , Germany.

Journal of Biopharmaceutical Statistics
|June 12, 2014
PubMed
Summary

This study evaluates methods for estimating a new drug's target dose, aiming for efficacy matching an active control. It analyzes maximum likelihood estimation and confidence intervals for linear dose-response models, considering non-normal error distributions.

Keywords:
Active controlDose-finding studyInverse regressionLinear model

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