Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

51
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
51

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of proprioceptive deficit on control of joint torques during force matching task in hemispheric stroke survivors.

Biomedical engineering letters·2026
Same author

Riluzole treatment paradoxically increases motoneuron excitability in ALS due to hyperactive homeostasis.

bioRxiv : the preprint server for biology·2026
Same author

A new perspective on spinal motoneuron persistent currents: Predictive compensation for muscle nonlinearities.

The Journal of physiology·2026
Same author

Motor unit discharge properties are modestly influenced by menstrual cycle-related fluctuations in sex hormone concentrations.

bioRxiv : the preprint server for biology·2026
Same author

Tracking spasticity dynamics in hemiparetic stroke survivors following cyproheptadine administration: a pilot study using controlled varying tendon indentation depths.

Frontiers in stroke·2026
Same author

A novel protocol to investigate the monoaminergic relationship between descending nociceptive and motor unit neuromodulation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025

Related Experiment Video

Updated: Apr 28, 2026

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

Published on: May 11, 2020

4.8K

Changes in motoneuron afterhyperpolarization duration in stroke survivors.

Aneesha K Suresh1, Xiaogang Hu2, Randall K Powers3

  • 1Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, Illinois; aneesha@uchicago.edu.

Journal of Neurophysiology
|June 13, 2014
PubMed
Summary

Stroke survivors with muscle weakness may have altered motor unit activation due to longer afterhyperpolarization (AHP) duration in motoneurons innervating paretic muscles. This may reduce firing rates and force production.

Keywords:
afterhyperpolarizationfirst dorsal interosseousmotor unitsparesisstroke

More Related Videos

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

22.7K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

19.8K

Related Experiment Videos

Last Updated: Apr 28, 2026

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

Published on: May 11, 2020

4.8K
In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

22.7K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

19.8K

Area of Science:

  • Neuroscience
  • Motor Control
  • Rehabilitation Science

Background:

  • Hemispheric brain injury from stroke often causes contralateral limb muscle weakness.
  • Motor unit activation alterations may contribute to this weakness, impacting firing rate modulation.

Purpose of the Study:

  • To investigate if stroke-induced hand muscle weakness is linked to changes in motor unit activation.
  • To examine afterhyperpolarization (AHP) duration differences in motoneurons of paretic versus non-paretic limbs.

Main Methods:

  • Used a novel surface EMG (sEMG) electrode to record motor units from the first dorsal interosseous muscle.
  • Decomposed sEMG data to derive single-motor unit events and analyze motoneuron discharge intervals.
  • Applied modified interval death rate (IDR) analysis to estimate AHP duration and coefficient of variation (CV) for discharge variability.

Main Results:

  • AHP duration was significantly longer in motoneurons of paretic muscles compared to contralateral muscles and control subjects.
  • Paretic motor unit discharges exhibited a lower coefficient of variation (CV) than contralateral or control units.
  • These findings suggest altered biophysical properties at the motoneuron level post-stroke.

Conclusions:

  • Increased AHP duration in paretic limb motoneurons may lead to reduced firing rates.
  • This motoneuron alteration could contribute to inefficient force production in paretic muscles after stroke.
  • The study highlights potential targets for neurorehabilitation strategies aimed at improving motor function.