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Two novel alleles HLA-DRB1*11:150 and HLA-DRB1*14:145 identified in Saudi individuals
H A Fakhoury1, N Cereb, D Jawdat
1Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi Arabia.
Abstract:
Two new HLA- DRB1 alleles were identified by sequence-based typing method (SBT) in 1100 participants in the Saudi Stem Cell Donor Registry. HLA-DRB1*11:150 differs from HLA-DRB1*11:01:01G by a single C to A substitution at nucleotide position 5580 in exon 2, resulting in an amino acid change from alanine to glutamic acid at position 74. HLA-DRB1*14:145 differs from HLA-DRB1*14:04 by a C to G substitution at nucleotide position 5511 in exon 2, resulting in an amino acid change from threonine to arginine at position 51.
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