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Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters

Tolga Unüvar1, Ahmet Anık, Gönül Catlı

  • 1Department of Pediatric Endocrinology, Medical Faculty, Adnan Menderes University, Aydın, 09100, Turkey, tunuvar@gmail.com.

Journal of Endocrinological Investigation
|June 13, 2014
PubMed

Insights

Isolated hyperthyrotropinemia (IH) is more common in obese children. In these children, thyroid-stimulating hormone (TSH) levels positively correlate with BMI-SDS and triglycerides, and negatively with free T4.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Thyroid Function

Background:

  • Obesity is a growing global health concern in children.
  • Thyroid dysfunction, including isolated hyperthyrotropinemia (IH), may be associated with obesity.
  • Understanding these associations is crucial for pediatric health management.

Purpose of the Study:

  • To determine the prevalence of IH in obese children.
  • To investigate the relationship between IH and anthropometric/metabolic parameters in obese children.

Main Methods:

  • Retrospective review of hospital records for obese children and matched healthy controls.
  • Analysis of thyroid function tests, including thyroid-stimulating hormone (TSH) and free T4 (fT4).
  • Correlation and regression analyses to assess relationships between TSH, BMI-SDS, and lipid profiles.

Main Results:

  • IH prevalence was significantly higher in obese children (9.2%) compared to controls (3.8%).
  • Obese children showed significant differences in BMI-SDS, TSH, and lipid parameters versus controls.
  • TSH positively correlated with BMI-SDS and triglycerides, and negatively with fT4 in obese subjects.

Conclusions:

  • Obese children exhibit a higher prevalence of isolated hyperthyrotropinemia.
  • TSH levels in obese children are influenced by BMI-SDS, triglyceride levels, and fT4 levels.
Abstract

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