Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gross Primary Productivity of Four European Ecosystems Constrained by Joint CO<sub>2</sub> and COS Flux Measurements.

Geophysical research letters·2019
Same author

Urban flux measurements reveal a large pool of oxygenated volatile organic compound emissions.

Proceedings of the National Academy of Sciences of the United States of America·2018
Same author

Urban eddy covariance measurements reveal significant missing NO<sub>x</sub> emissions in Central Europe.

Scientific reports·2017
Same author

[What do prostate cancer patients know about smoking? : Results of a bicentric questionnaire study (KRAUT study)].

Der Urologe. Ausg. A·2016
Same author

Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1.

Genes, brain, and behavior·2015
Same author

Atmospheric benzenoid emissions from plants rival those from fossil fuels.

Scientific reports·2015
Same journal

Dissecting the Strain and Sex Specific Connectome Signatures of Unanesthetized C57BL/6J and DBA/2J Mice Using Magnetic Resonance Imaging.

Genes, brain, and behavior·2026
Same journal

Exploring the Association Between Mental Disorders and Various Arrhythmias via Mendelian Randomization Methods.

Genes, brain, and behavior·2026
Same journal

Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.

Genes, brain, and behavior·2026
Same journal

∆FOSB in the Nucleus Accumbens Core Is Required for Increased Anxiety, but Not Decreased Social Motivation, Following Estrogen Withdrawal in Female Mice.

Genes, brain, and behavior·2026
Same journal

Taste Preferences Shape Disease Susceptibility via Heritable Nutrient Predispositions: A Behavior-Gene Coevolution Framework.

Genes, brain, and behavior·2026
Same journal

Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler Mice Compared to Controls.

Genes, brain, and behavior·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

1.7K

Do individually ventilated cage systems generate a problem for genetic mouse model research?

W Logge1, J Kingham, T Karl

  • 1Neuroscience Research Australia (NeuRA), Randwick; Schizophrenia Research Institute, Darlinghurst.

Genes, Brain, and Behavior
|June 13, 2014
PubMed
Summary
This summary is machine-generated.

Individually ventilated cages (IVCs) alter schizophrenia-relevant behaviors in mouse models. This housing change can impact research findings, particularly prepulse inhibition deficits in male mice, necessitating careful consideration for genetic studies.

Keywords:
Behaviourdata reliabilityfilter-top cagesgenetic mouse modelindividually ventilated cage systemlaboratory housingmouse mutant phenotypeneuregulin 1schizophreniavalidity of mouse models

More Related Videos

Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

20.6K
A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

3.6K

Related Experiment Videos

Last Updated: Apr 28, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

1.7K
Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

20.6K
A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

3.6K

Area of Science:

  • Neuroscience
  • Animal Models
  • Genetics

Background:

  • Individually ventilated cage (IVC) systems are novel housing for laboratory mice, differing from conventional filter-top cages (FILTER).
  • The impact of IVC housing on the phenotypes of genetic mouse models is largely unknown.
  • Previous studies suggest IVC housing can alter inbred mouse strain phenotypes.

Purpose of the Study:

  • To systematically compare the behavioral phenotype of a neuregulin 1 (Nrg1) mutant mouse model for schizophrenia housed in FILTER versus IVC systems.
  • To investigate the consequences of IVC housing on established schizophrenia-relevant endophenotypes.
  • To assess sex-dependent effects of IVC housing on mouse behavior.

Main Methods:

  • Comparison of TM Nrg1 HET mice (schizophrenia model) housed in FILTER cages versus IVC systems.
  • Systematic behavioral phenotyping across multiple test paradigms.
  • Analysis of sex-specific behavioral differences between housing conditions.

Main Results:

  • IVC housing diminished the prepulse inhibition deficit in male Nrg1 mutant mice, a schizophrenia-relevant endophenotype.
  • IVC housing exhibited a sex-dependent, moderate effect on the locomotive phenotype of Nrg1 mice.
  • Behavioral alterations due to IVC housing were less pronounced in female mice.

Conclusions:

  • Transferring mouse mutant colonies to IVC systems can alter disease-relevant behaviors, potentially challenging the face validity of these models.
  • Researchers upgrading to IVC systems must be aware of potential impacts on their genetic mouse models.
  • Future publications should detail cage systems used to ensure data comparability across research sites.