Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Circuits01:25

Neural Circuits

3.0K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antisense oligonucleotide therapeutic approach for Timothy syndrome.

Nature·2024
Same author

The ammonia oxidizing bacterium Nitrosomonas eutropha blocks T helper 2 cell polarization via the anti-inflammatory cytokine IL-10.

Scientific reports·2021
Same author

Current Controversy: Spikes, Bursts, and Synchrony in Generalized Absence Epilepsy: Unresolved Questions Regarding Thalamocortical Synchrony in Absence Epilepsy.

Epilepsy currents·2019
Same author

Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems.

Cell·2018
Same author

On the handling of stimulation artifacts during simultaneous electroencephalography (EEG) and transcranial low field strength magnetic stimulation (LFMS).

Brain stimulation·2017
Same author

Criminal Minds: Cav3.2 Channels Are the Culprits, but NMDAR Are the Co-Conspirators.

Epilepsy currents·2016

Related Experiment Video

Updated: Apr 28, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
10:06

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

12.2K

Parallel midbrain microcircuits perform independent temporal transformations.

C Alex Goddard1, John Huguenard2, Eric Knudsen3

  • 1Department of Neurobiology, Stanford University, Stanford, California 94305, and cgoddard@stanford.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|June 13, 2014
PubMed
Summary
This summary is machine-generated.

The optic tectum (OT) and nucleus isthmi pars magnocellularis (Imc) in chickens use specialized neural circuits. These circuits enable selective attention by transforming sensory input into distinct temporal firing patterns for different brain targets.

Keywords:
attentioncolliculusdecisioninhibitiontectum

More Related Videos

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
06:30

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

9.4K
Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
08:45

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

14.3K

Related Experiment Videos

Last Updated: Apr 28, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
10:06

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

12.2K
Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
06:30

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

9.4K
Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
08:45

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

14.3K

Area of Science:

  • Neuroscience
  • Sensory processing
  • Attention mechanisms

Background:

  • Selective attention is vital for survival, involving midbrain networks.
  • In birds, the optic tectum (OT) and nucleus isthmi pars magnocellularis (Imc) collaborate for stimulus selection.
  • The chicken OT and Imc system is a model for studying attention and gaze control.

Purpose of the Study:

  • To investigate the source of high-frequency inhibitory activity in the Imc.
  • To understand how OT layer 10 neurons generate different temporal firing patterns.
  • To elucidate the role of microcircuit specialization in sensory processing.

Main Methods:

  • Electrophysiological recordings from individual neurons in chicken OT layer 10.
  • Analysis of local field potentials (LFPs) to measure network activity.
  • Tracing neuronal projections to differentiate downstream targets.

Main Results:

  • OT layer 10 neurons projecting to the Imc exhibit specialized biophysical properties.
  • These neurons transform afferent input into high firing rates (~130 spikes/s).
  • Neighboring OT layer 10 neurons projecting elsewhere produce lower-frequency, periodic discharge patterns.

Conclusions:

  • The intermediate layers of the OT contain parallel microcircuits with distinct temporal output patterns.
  • These microcircuits are tailored for the specific functions of their downstream targets.
  • This specialization allows for differential processing of sensory information crucial for attention.