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Updated: Apr 28, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
A sertraline/valproic acid drug interaction: Case Reports
Abstract:
Clinicians are frequently faced with the challenge of treating patients diagnosed within the wide spectrum of bipolar depression. Because no one single mood-stabilizing agent can effectively treat depression, and antidepressant agents can trigger mania, these classes are employed together to treat bipolar depression. Because psychotropic medications are frequently mixed in treating a wide variety of psychiatric conditions, clinicians must remain vigiliant for possible drug interactions, which can cause unnecessary morbidity. A case is reported in which a patient suffering from bipolar depression experienced a drug interaction involving sertraline and valproic acid. To date there have been no reported cases of drug interactions between these two psychotropic medications. (Int J Psych Clin Pract 1999; 3: 287-288).
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