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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

7.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
MicroRNAs01:22

MicroRNAs

21.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.0K
RNA Interference01:23

RNA Interference

24.3K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Decoding RNA Methylation's Role in Pancreatic Cancer - A Single-Base Resolution Study
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Author Spotlight: Decoding RNA Methylation's Role in Pancreatic Cancer - A Single-Base Resolution Study

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[Non-coding RNA and pancreatic cancer].

Linlin Chen1, Huan Gu, Jie Peng

  • 1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|June 13, 2014
PubMed
Summary

Non-coding RNAs regulate gene expression and are vital in pancreatic cancer development. Understanding their mechanisms is key for diagnosis, treatment, and prognosis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs) are crucial regulators of gene expression.
  • ncRNAs are implicated in fundamental cellular processes like differentiation, proliferation, and apoptosis.
  • Dysregulation of ncRNAs is linked to cancer occurrence, invasion, and metastasis.

Purpose of the Study:

  • To explore the role and molecular mechanisms of non-coding RNA in pancreatic cancer.
  • To understand how ncRNAs influence pancreatic cancer cell growth and apoptosis.

Main Methods:

  • The study reviews the known molecular mechanisms by which ncRNAs impact pancreatic cancer.
  • Analysis of ncRNA involvement in epigenetic modification, transcriptional regulation, and DNA damage repair.

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Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
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Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets

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Last Updated: Apr 28, 2026

Author Spotlight: Decoding RNA Methylation's Role in Pancreatic Cancer - A Single-Base Resolution Study
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Author Spotlight: Decoding RNA Methylation's Role in Pancreatic Cancer - A Single-Base Resolution Study

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Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
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Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
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Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets

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Main Results:

  • Non-coding RNAs regulate pancreatic cancer cell growth and apoptosis through various mechanisms.
  • These mechanisms include mediating genome hyper-methylation, transcriptional regulation, and DNA damage repair.

Conclusions:

  • Non-coding RNAs play a significant role in pancreatic cancer development.
  • Understanding ncRNA mechanisms offers potential for improved diagnosis, treatment, and prognosis of pancreatic cancer.