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[Carotid intima-media thickness and estimated glomerular filtration rate in hypertensive patients]

Pingting Yang1, Hong Yuan, Chunyan Weng

  • 1Health Management Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|June 13, 2014
PubMed

Insights

In hypertensive patients, increased carotid intima-media thickness (cIMT) is linked to reduced kidney function, indicated by lower estimated glomerular filtration rate (eGFR). This association highlights a connection between vascular changes and chronic kidney disease progression.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Hypertension Research

Background:

  • Hypertension is a major risk factor for both cardiovascular disease and chronic kidney disease (CKD).
  • Carotid atherosclerosis, measured by carotid intima-media thickness (cIMT), is a marker of subclinical cardiovascular disease.
  • The relationship between carotid atherosclerosis and renal function in hypertensive individuals requires further elucidation.

Purpose of the Study:

  • To investigate the association between carotid atherosclerosis and renal function in a cohort of hypertensive patients.
  • To determine if cIMT is a predictor of reduced estimated glomerular filtration rate (eGFR) in this population.

Main Methods:

  • A cross-sectional study involving 2,809 hypertensive patients (mean age 56.59±10.79 years).
  • Carotid intima-media thickness (cIMT) assessed using B-mode ultrasonography.
  • Chronic kidney disease (CKD) evaluated by estimated glomerular filtration rate (eGFR) calculated using the Cockcroft-Gault method; patients categorized into normal, thickened, and plaque groups based on cIMT.

Main Results:

  • Patients with thicker cIMT or carotid plaques exhibited significantly lower eGFR compared to those with normal cIMT.
  • Logistic regression revealed age, smoking, systolic blood pressure, and eGFR as significant correlates of cIMT.
  • eGFR was identified as an independent risk factor for cIMT in men, but not in women.

Conclusions:

  • A thicker cIMT is associated with a lower eGFR in hypertensive patients.
  • Progressive thickening of the carotid intima-media correlates with a gradual decline in renal function.
  • These findings suggest that carotid atherosclerosis development contributes to early-stage kidney dysfunction in hypertension.
Abstract

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