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Osteoarticular infections in young children: what has changed over the last years?
Dimitri Ceroni1, Georgios Kampouroglou2, Raimonda Valaikaite2
1Paediatric Orthopaedic Unit, Department of Child and Adolescent, University of Geneva Hospitals and University of Geneva Faculty of Medicine, Switzerland; dimitri.ceroni@hcuge.ch.
Insights
Pediatric osteoarticular infections cause significant childhood morbidity and long-term growth issues. Recent advancements in understanding their epidemiology, diagnosis, and treatment are crucial for clinicians managing these complex bone and joint infections.
Area of Science:
- Pediatrics
- Infectious Diseases
- Orthopedics
Background:
- Osteoarticular infections are a major cause of childhood morbidity worldwide.
- These infections can lead to severe, long-lasting sequelae, particularly affecting growth.
- They manifest as osteomyelitis, septic arthritis, or spondylodiscitis, originating from hematogenous, contiguous, or direct inoculation sources.
Purpose of the Study:
- To review recent concepts in the epidemiology, pathophysiology, and microbiology of pediatric bone and joint infections.
- To discuss current clinical presentations, diagnostic approaches, and treatment strategies.
- To highlight evolving principles essential for effective clinical management.
Main Methods:
- Review of current literature and recent advancements in the field.
- Synthesis of updated information on diagnostic assays and microbiological causes.
- Discussion of clinical, epidemiological, and microbiological aspects.
Main Results:
- Significant evolution in diagnostic assays and understanding of microbiological causes.
- Updated insights into the epidemiology and pathophysiology of these infections.
- Current treatment principles have been refined based on new evidence.
Conclusions:
- Clinicians require updated knowledge on pediatric osteoarticular infections for optimal patient care.
- Newer concepts guide the evaluation and treatment of bone and joint infections in children.
- Effective management relies on understanding recent advancements in diagnosis and therapy.
Abstract:
Osteoarticular infections remain a significant cause of morbidity worldwide in young children. They can have a devastating impact with a high rate of serious and long-lasting sequelae, especially on remaining growth. Depending on the localisation of infection, they manifest as osteomyelitis, septic arthritis, a combination of both (i.e., osteomyelitis with adjacent septic arthritis) or spondylodiscitis. Osteoarticular infections can be divided into three types according to the source of infection: haematogenous; secondary to contiguous infection; or secondary to direct inoculation. During the last few years, many principles regarding diagnostic assays and the microbiological causes of these infections have evolved in a significant manner. In the present current-opinion review, we discuss recent concepts regarding epidemiology, physiopathology, and the microbiology of bone and joint infections in young children, as well as clinical presentations, diagnosis, and treatment of these infections. Clinicians caring for children need to be especially well versed in these newer concepts as they can be used to guide evaluation and treatment.
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