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Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM
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Photonic crystal based microscale flow cytometry.

Justin Stewart, Anna Pyayt

    Optics Express
    |June 13, 2014
    PubMed
    Summary

    A novel on-chip micro-flow cytometry system using photonic crystals enables cell counting and shape analysis. This technology offers a new method for analyzing cell characteristics based on light transmission changes.

    Area of Science:

    • Biophotonics
    • Nanotechnology
    • Cellular analysis

    Background:

    • Traditional flow cytometry methods can be complex and expensive.
    • Miniaturization of analytical systems is crucial for point-of-care applications.
    • Photonic crystals offer unique light manipulation properties for sensing.

    Purpose of the Study:

    • To develop a miniaturized on-chip micro-flow cytometry system.
    • To utilize photonic crystals for label-free cell detection and characterization.
    • To demonstrate the system's capability for cell counting and shape-dependent signal analysis.

    Main Methods:

    • Design and simulation of an on-chip micro-flow cytometry system.
    • Integration of photonic crystals for light-cell interaction.

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  • Modeling using OptiFDTD software to analyze light transmission spectra.
  • Experimental validation of cell counting and shape differentiation.

    • Main Results:

    • Successful demonstration of the potential for on-chip cell counting.
    • Establishment of a direct correlation between signal distribution and cell shape.
    • Quantification of light transmission changes due to cell presence, size, and shape.

    Conclusions:

    • The proposed photonic crystal-based micro-flow cytometry is a viable platform for cellular analysis.
    • The system offers label-free detection and characterization of cells on-chip.
    • This technology has potential applications in biological research and medical diagnostics.