Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium-induced nephrotic syndrome.

I K Wood1, D X Parmelee, J W Foreman

  • 1Division of Child Psychiatry, Virginia Treatment Center for Children, Richmond.

The American Journal of Psychiatry
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impacted Third Molars.

International dental journal (Philadelphia, Pa.)·2023
Same author

Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates.

Journal of perinatology : official journal of the California Perinatal Association·2013
Same author

Mercier's aspheric manufacturability index.

Applied optics·2010
Same author

Simple numerical measure of the manufacturability of aspheric optical surfaces.

Applied optics·2010
Same author

Variation of energy throughput with off-axis angle for the S056 x-ray telescope.

Applied optics·2010
Same author

Computation of RMS Spot Radii by Ray Tracing.

Applied optics·2010

Lithium treatment can cause nephrotic syndrome, a rare kidney condition, even at normal doses. This condition, characterized by minimal change disease, often resolves after stopping lithium.

Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Background:

  • Lithium is a mood stabilizer used to treat bipolar disorder.
  • Nephrotic syndrome is a kidney disorder characterized by protein in the urine.
  • Adverse renal effects of lithium are uncommon but can be serious.

Observation:

  • Lithium-induced nephrotic syndrome is a rare, idiosyncratic adverse renal effect.
  • It can occur at therapeutic plasma lithium levels.
  • Renal biopsies show fusion of foot processes of renal epithelial cells (minimal change disease).

Findings:

  • The syndrome is typically reversible upon lithium discontinuation, though corticosteroids may be needed.
  • No specific risk factors identify individuals prone to developing this condition.

Related Experiment Videos

  • This review includes eight previously published cases and one new case of lithium-induced nephrotic syndrome in an adolescent.

    • Implications:

    • Clinicians should be aware of the potential for lithium-induced nephrotic syndrome.
    • Early recognition and discontinuation of lithium are crucial for management.
    • Further research may be needed to identify individuals at risk.