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The microbiota-gut-brain axis in functional gastrointestinal disorders
Giada De Palma1, Stephen M Collins1, Premysl Bercik1
1Farncombe Family Digestive Health Research Institute; McMaster University; Hamilton, Canada.
Gut Microbes
|June 13, 2014
Summary
Functional gastrointestinal disorders (FGIDs) involve the gut-brain axis and altered gut microbiota. Research shows probiotics and antibiotics can improve gastrointestinal and psychological symptoms in FGID patients.
Area of Science:
- Gastroenterology
- Neurogastroenterology
- Microbiome Research
Background:
- Functional gastrointestinal disorders (FGIDs) are common, impacting quality of life and healthcare systems.
- The pathophysiology of FGIDs is complex, involving interactions between gut physiology and psychological factors.
- The gut-brain axis is a key pathway where gut and brain influence each other.
Purpose of the Study:
- To review the existing literature on functional gastrointestinal disorders (FGIDs).
- To explore the role of the microbiota-gut-brain axis in FGIDs.
- To summarize findings on the impact of gut microbiota in FGIDs like Irritable Bowel Syndrome.
Main Methods:
- Literature review of studies on FGIDs and the microbiota-gut-brain axis.
- Analysis of research comparing gut microbiota composition in FGID patients versus healthy individuals.
- Examination of treatment outcomes for probiotics and antibiotics in FGID management.
Main Results:
- FGID patients, particularly those with Irritable Bowel Syndrome, exhibit distinct gut microbiota profiles.
- Alterations in intestinal microbiota are implicated in the development and symptoms of FGIDs.
- Therapeutic interventions targeting the microbiota, such as probiotics and antibiotics, show benefits.
Conclusions:
- The intestinal microbiota is a critical component of the microbiota-gut-brain axis in FGIDs.
- Modulating the gut microbiota may offer therapeutic strategies for FGIDs.
- Further research into the microbiota-gut-brain axis is essential for understanding and treating FGIDs.
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