Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Study on effect of coptidis rhizoma on red blood cells of normal mice and its antioxidant property].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2013
Same author

General framework to histogram-shifting-based reversible data hiding.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2013
Same author

The prevalences of Neisseria gonorrhoeae and Chlamydia trachomatis infections among female sex workers in China.

BMC public health·2013
Same author

[Study on allocation rules of common nutrients in Scutellaria baicalensis in different phenological periods by ICP-OES].

Guang pu xue yu guang pu fen xi = Guang pu·2013
Same author

Sesterterpenoids.

Natural product reports·2013
Same author

14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists·2013

Related Experiment Video

Updated: Apr 28, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

9.7K

Zwitterionic red fluorescent polymeric nanoparticles for cell imaging.

Haiyin Li1, Xiqi Zhang, Xiaoyong Zhang

  • 1College of Chemistry and Pharmaceutical Sciences, Qingdao Agriculture University, Qingdao, 266109, P. R. China.

Macromolecular Bioscience
|June 14, 2014
PubMed
Summary

Researchers developed novel red fluorescent polymeric nanoparticles (FPNs) using phospholipid monomers and aggregation-induced emission (AIE) dyes. These biocompatible FPNs self-assemble in solution and show promise for cell imaging applications.

Keywords:
aggregation-induced emissioncell imagingfluorescent polymeric nanoparticlesphospholipid monomerszwitterionic

More Related Videos

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

17.5K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

6.9K

Related Experiment Videos

Last Updated: Apr 28, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

9.7K
Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

17.5K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

6.9K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Developing advanced fluorescent materials for biological applications is crucial.
  • Aggregation-induced emission (AIE) dyes offer unique photophysical properties.
  • Zwitterionic polymers can self-assemble into nanoparticles with good biocompatibility.

Purpose of the Study:

  • To synthesize novel cross-linked zwitterionic fluorescent copolymers.
  • To investigate the self-assembly of these copolymers into fluorescent polymeric nanoparticles (FPNs).
  • To evaluate the potential of these FPNs for cell imaging.

Main Methods:

  • Reversible addition-fragmentation transfer polymerization to incorporate phospholipid monomers and AIE dye-based dimers.
  • Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy for copolymer characterization.
  • UV-visible absorption, fluorescence spectroscopy, transmission electron microscopy, and dynamic light scattering for FPN analysis.
  • Biocompatibility and cell uptake studies.

Main Results:

  • Successful synthesis of cross-linked zwitterionic fluorescent copolymers.
  • Formation of stable, bright red fluorescent polymeric nanoparticles (FPNs) in physiological solution.
  • Demonstrated stable dispersibility of FPNs even below the critical micelle concentration.
  • Exhibited excellent biocompatibility and cellular uptake.

Conclusions:

  • The developed zwitterionic fluorescent copolymers effectively self-assemble into red FPNs.
  • These FPNs possess desirable properties for advanced bioimaging applications.
  • The FPNs show significant potential for biocompatible cell imaging.