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Updated: Apr 28, 2026
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Comparison of block and event-related experimental designs in diffusion-weighted functional MRI
Rebecca J Williams1, Katie L McMahon, Julia Hocking
1University of Queensland, Centre for Advanced Imaging, Brisbane, Australia; University of Queensland, Queensland Brain Institute, Brisbane, Australia.
Purpose:
To compare diffusion-weighted functional magnetic resonance imaging (DfMRI), a novel alternative to the blood oxygenation level-dependent (BOLD) contrast, in a functional MRI experiment.
Materials And Methods:
Nine participants viewed contrast reversing (7.5 Hz) black-and-white checkerboard stimuli using block and event-related paradigms. DfMRI (b = 1800 mm/s(2)) and BOLD sequences were acquired. Four parameters describing the observed signal were assessed: percent signal change, spatial extent of the activation, the Euclidean distance between peak voxel locations, and the time-to-peak of the best fitting impulse response for different paradigms and sequences.
Results:
The BOLD conditions showed a higher percent signal change relative to DfMRI; however, event-related DfMRI showed the strongest group activation (t = 21.23, P < 0.0005). Activation was more diffuse and spatially closer to the BOLD response for DfMRI when the block design was used. DfMRIevent showed the shortest TTP (4.4 ± 0.88 sec).
Conclusion:
The hemodynamic contribution to DfMRI may increase with the use of block designs.
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