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Updated: Apr 28, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
New cholinesterase inhibitors from Garcinia atroviridis
Wen-Nee Tan1, Melati Khairuddean1, Keng-Chong Wong1
1School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Abstract:
A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge.
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