Related Experiment Video
Updated: Apr 28, 2026
Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
Use of tranexamic acid in infants undergoing choroid plexus papilloma surgery: a report of two cases
Ji H Phi1, Susan M Goobie, Ki H Hong
1Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Korea.
Insights
Tranexamic acid (TXA) may reduce bleeding during surgery for choroid plexus papilloma (CPP) in infants. This study found minimal blood loss in two infants receiving TXA, suggesting its potential utility for this vulnerable population.
Area of Science:
- Pediatric Neurosurgery
- Surgical Hemostasis
- Oncology
Background:
- Choroid plexus papilloma (CPP) is a highly vascular tumor common in infants.
- Surgical removal of CPPs requires careful management of blood loss.
- Craniofacial surgery in infants has previously shown the benefit of tranexamic acid (TXA).
Observation:
- This report details the use of tranexamic acid (TXA) in two infants undergoing surgical removal of choroid plexus papilloma (CPP).
- TXA was administered perioperatively to assess its hemostatic properties.
- The administration aimed to reduce intra-operative bleeding during tumor resection.
Findings:
- Gross total surgical resection of CPP was achieved in both patients.
- Patients remained hemodynamically stable throughout the perioperative period.
- Total calculated blood loss was minimal, less than 20% of total circulating blood volume.
Implications:
- This is the first report on tranexamic acid (TXA) use in pediatric choroid plexus papilloma (CPP) surgery.
- TXA is an easily administered hemostatic agent with potential benefits for infants.
- Further studies are warranted to confirm TXA's efficacy in reducing blood loss in this pediatric population.
Abstract:
Choroid plexus papilloma (CPP) is a highly vascular tumor of infancy. Reducing blood loss is the key to successful surgical removal of CPPs. Tranexamic acid (TXA) is efficacious in reducing bleeding in craniofacial surgery for infants. This report demonstrates the potential utility of TXA for decreasing blood loss in the removal of vascular tumors in infants. We administered tranexamic acid to two infants with CPP during surgical removal to potentially aid hemostasis and therefore lessen intra-operative bleeding. Gross total surgical resection was accomplished; the patients were hemodynamically stable perioperatively, and the total calculated blood loss was minimal at <20% of the patients' total circulating blood volume. This is the first report of tranexamic acid administration for CPP surgery in children. TXA is an easily administered hemostatic agent and may merit further study as an agent to help reduce intra-operative blood loss in this vulnerable population.
