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Related Experiment Video

Updated: Apr 28, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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Hippocampus age-related microstructural changes in schizophrenia: a case-control mean diffusivity study.

Chiara Chiapponi1, Fabrizio Piras1, Sabrina Fagioli1

  • 1IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory, Via Ardeatina 306, 00179 Rome, Italy.

Schizophrenia Research
|June 14, 2014
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Summary

Schizophrenia patients show early microstructural damage in the hippocampus, indicated by increased mean diffusivity. These changes worsen with age, suggesting ongoing damage throughout the lifespan.

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AgeHippocampusMean diffusivitySchizophreniaTrajectories

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurology

Background:

  • Macrostructural abnormalities of the hippocampus are known in schizophrenia.
  • Microstructural integrity is crucial for hippocampal function.

Purpose of the Study:

  • To investigate age-related microstructural changes in the hippocampus in schizophrenia.
  • To characterize hippocampal mean diffusivity as an index of microstructural damage.

Main Methods:

  • Neuroimaging study involving 85 schizophrenia patients and 85 healthy controls.
  • Analysis of covariance to assess mean diffusivity differences based on diagnosis and age.

Main Results:

  • Patients with schizophrenia exhibited an early increase in hippocampal mean diffusivity.
  • This increase in mean diffusivity was found in both the right and left hippocampi.
  • The microstructural damage in the hippocampus progressed with age in patients.

Conclusions:

  • Microstructural hippocampal changes in schizophrenia are not limited to a specific age range.
  • These findings highlight ongoing neurodegenerative processes in the hippocampus associated with schizophrenia.