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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
[Value of evaluating diastolic function with the single-beat E/(e'×s) obtained by dual doppler echocardiograph in
Jingjing Wang1, Yundai Chen1, Jing Wang1
1Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Insights
The ratio E/(e'×s) effectively estimates diastolic dysfunction in coronary heart disease patients. However, combining it with E/e' does not improve prediction accuracy for this condition.
Area of Science:
- Cardiology
- Echocardiography
- Diastolic Function
Background:
- Left ventricular diastolic dysfunction is a key indicator in coronary heart disease (CHD).
- Accurate assessment of diastolic function is crucial for managing CHD patients with preserved systolic function.
Purpose of the Study:
- To evaluate the utility of the E/(e'×s) ratio, derived from dual Doppler echocardiography, in assessing left ventricular diastolic dysfunction.
- To compare the predictive value of E/(e'×s) with the established E/e' ratio in this patient group.
Main Methods:
- Seventy-seven CHD patients with preserved systolic function underwent echocardiography to obtain E, e', and s values.
- E/(e'×s) and E/e' ratios were calculated and correlated with left ventricular end-diastial pressure (LVEDP) from catheterization.
- Receiver operating characteristic (ROC) analysis determined optimal cut-off values for predicting diastolic dysfunction (LVEDP ≥ 12 mmHg).
Main Results:
- Both E/(e'×s) and E/e' showed significant correlations with LVEDP (r=0.68 and r=0.79, respectively; P < 0.01).
- Optimal cut-off values were E/(e'×s) of 1.2 (AUC=0.85) and E/e' of 9.2 (AUC=0.87).
- Combined use of E/(e'×s) ≥ 1.2 and E/e' ≥ 9.2 yielded a sensitivity of 83% and specificity of 71% (AUC=0.87).
Conclusions:
- The E/(e'×s) ratio is a reliable indicator of diastolic function in coronary heart disease patients.
- While E/(e'×s) demonstrates good predictive value, its combination with E/e' did not enhance the prediction of diastolic dysfunction in this cohort.
Objective:
To assess the value of E/(e'×s) in estimating left ventricular diastolic dysfunction in patients with coronary heart disease by dual Doppler echocardiograph.
Methods:
Seventy-seven consecutive coronary heart disease patients with preserved systolic function underwent echocardiographic study were included. The E, e'and s were obtained by the dual Doppler echocardiography and E/(e'×s), E/e' were calculated. All patients underwent left ventricular catheterization to measure left ventricular end diastolic pressure (LVEDP). The relationship between E/(e'×s), E/e' and LVEDP were analyzed. Patients were divided into normal diastolic function (LVEDP < 12 mmHg, 1 mmHg = 0.133 kPa) and diastolic dysfunction group (LVEDP ≥ 12 mmHg) .
Results:
(1) Pearson correlation analysis showed that both E/(e'×s) and E/e' correlated well with LVEDP (r = 0.68 and r = 0.79, both P < 0.01). (2)Using receiver operating characteristic analysis, the optimal cut-off for E/(e'×s) was 1.2(sensitivity was 80%, specificity was 77%,AUC was 0.85) and for E/e' was 9.2(sensitivity was 74%, specificity was 81%,AUC was 0.87) to predict left ventricular diastolic dysfunction. When combined cut-offs of E/(e'×s) ≥ 1.2 and E/e' ≥ 9.2, the sensitivity and specificity of predicting left ventricular diastolic dysfunction were 83% and 71% respectively, and AUC was 0.87.
Conclusions:
E/(e'×s) can correctly reflect diastolic function status in patients with coronary artery disease. However, combined use of E/(e'×s)and E/e' does not add the prediction value on diastolic dysfunction in this patient cohort.
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