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Updated: Apr 28, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Synthesis of heterocycles through transition-metal-catalyzed isomerization reactions
Mette Ishoey1, Thomas E Nielsen
1Department of Chemistry, Technical University of Denmark, Kemitorvet, Build. 201, 2800 Kgs. Lyngby (Denmark), Fax: (+45) 45-88-31-36.
Abstract:
Metal-catalyzed isomerization of N- and O-allylic systems is emerging as an effective method to form synthetically useful iminium and oxocarbenium intermediates. In the presence of tethered nucleophiles, several recent examples illuminate this approach as a powerful strategy for the synthesis of structurally complex and diverse heterocycles. In this Concept article, we attempt to cover this area of research through a selection of recent versatile examples.
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