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Updated: Apr 28, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

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Published on: May 18, 2018

Dermatofibrosarcoma protuberans, version 1.2014.

Christopher K Bichakjian¹, Thomas Olencki¹, Murad Alam¹

¹From University of Michigan Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Roswell Park Cancer Institute; UC San Diego Moores Cancer Center; Moffitt Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Memorial Sloan-Kettering Cancer Center; University of Colorado Cancer Center; Fred & Pamela Buffett Cancer Center at The Nebraska Medical Center; The University of Texas MD Anderson Cancer Center; Duke Cancer Institute; Fox Chase Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Dana-Farber/Brigham and Women's Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

Journal of the National Comprehensive Cancer Network : JNCCN

|June 14, 2014

Summary

This summary is machine-generated.

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor with high recurrence risk. New NCCN guidelines emphasize pathology, including immunohistochemistry and cytogenetics, for accurate diagnosis and management of this challenging cancer.

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Area of Science:

Oncology
Pathology
Genetics

Background:

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue neoplasm.
DFSP presents a high risk of local recurrence but a low risk of metastasis.
Management of DFSP requires a multidisciplinary approach.

Framework:

The NCCN Guidelines for DFSP offer updated recommendations for patient care.
Key updates include the addition of a Principles of Pathology section.
This section focuses on the pathologic assessment of DFSP.

Implementation:

Accurate diagnosis of DFSP is crucial due to its potential to mimic other skin lesions.
Immunohistochemical studies are frequently necessary for definitive diagnosis.
Cytogenetic testing for the t(17;22)(q22;q13) translocation aids in differentiating DFSP from similar tumors.

Implications:

Enhanced diagnostic accuracy improves patient outcomes for DFSP.
Standardized pathologic assessment ensures consistent and reliable diagnoses.
Genetic insights into DFSP support differential diagnosis and inform treatment strategies.