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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Diffusion-weighted imaging thermometry in multiple sclerosis.

Asari Sai1, Taro Shimono, Koji Sakai

  • 1Department of Radiology, Osaka City University Graduate School of Medicine Osaka, Japan.

Journal of Magnetic Resonance Imaging : JMRI
|June 14, 2014
PubMed
Summary

Brain temperature is significantly lower in multiple sclerosis (MS) patients compared to healthy individuals. This finding may indicate reduced brain metabolism in those with MS.

Keywords:
brain temperaturediffusion-weighted imagingdiffusion-weighted thermometrymultiple sclerosis

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Thermometry

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease.
  • Brain temperature dysregulation is a potential factor in MS pathophysiology.
  • Non-invasive methods for measuring brain temperature are needed.

Purpose of the Study:

  • To prospectively investigate brain temperature in MS patients versus healthy controls using MR diffusion-weighted imaging thermometry.
  • To compare brain temperatures between the two groups.
  • To examine correlations between brain temperature, disease duration, and Expanded Disability Status Scale (EDSS) in MS patients.

Main Methods:

  • 13 MS patients and 13 age-matched healthy controls were scanned using a 3.0 Tesla MR unit.
  • Brain temperature was measured via diffusion-weighted imaging-based MR thermometry of the lateral ventricles.
  • Student's t-test and Pearson's correlation coefficient were used for statistical analysis.

Main Results:

  • Median brain temperature was significantly lower in MS patients (35.81°C) than in healthy controls (36.29°C) (P=0.020).
  • No significant correlation was found between brain temperature and disease duration (r=-0.382, P=0.198).
  • No significant correlation was found between brain temperature and EDSS (r=-0.026, P=0.933).

Conclusions:

  • Brain temperature is significantly reduced in multiple sclerosis patients.
  • Lower brain temperature in MS may suggest decreased brain metabolism.
  • Further research is warranted to explore the implications of brain temperature in MS.