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Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophils.

Susanne Radonjic-Hösli¹, Hans-Uwe Simon

¹Institute of Pharmacology, University of Bern, Bern, Switzerland.

Chemical Immunology and Allergy

|June 14, 2014

Summary

Eosinophils, identified by their granular staining, are multifunctional immune cells. Research into their regulation and function has revealed their roles in host defense, tissue damage, and immunomodulation.

Area of Science:

Immunology
Hematology

Background:

The identification and classification of eosinophils have evolved since the 19th century.
Early descriptions focused on granular cell morphology, with Paul Ehrlich's staining methods enabling precise classification.
The precise roles of eosinophils in disease have been a subject of ongoing research.

Purpose of the Study:

To review the historical understanding and current knowledge of eosinophil function.
To highlight advancements in understanding eosinophil regulatory mechanisms and their implications in disease.

Main Methods:

Historical literature review.
Analysis of studies involving eosinophil knock-out mice models.
Evaluation of therapeutic strategies targeting eosinophil levels.

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Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

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Published on: July 28, 2016

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Main Results:

Eosinophils are now recognized as multifunctional cells involved in host defense.
Their roles extend to tissue damage, remodeling, and immunomodulation.
Research has elucidated regulatory mechanisms of eosinopoiesis, leading to therapeutic interventions.

Conclusions:

Eosinophils play complex roles in health and disease.
Further research continues to refine our understanding of these versatile immune cells.