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A retrospective descriptive study of oral azole antifungal agents in patients with patch test-negative head and neck

Benjamin H Kaffenberger1, Jason Mathis2, Matthew J Zirwas3

  • 1Division of Dermatology, Ohio State University College of Medicine, Columbus, Ohio; Ohio State University College of Medicine, Columbus, Ohio.

Journal of the American Academy of Dermatology
|June 14, 2014
PubMed
Abstract

Insights

Systemic azole antifungals effectively treated head and neck dermatitis in adults. Over two-thirds of patients experienced symptom improvement, demonstrating the efficacy of this treatment approach.

Area of Science:

  • Dermatology
  • Mycology
  • Internal Medicine

Background:

  • Head and neck dermatitis is a specific form of atopic dermatitis.
  • This condition is primarily caused by Malassezia yeast infections.

Purpose of the Study:

  • To assess the effectiveness of systemic azole antifungal medications.
  • To evaluate treatment outcomes for patients diagnosed with head and neck dermatitis.

Main Methods:

  • Retrospective analysis of electronic medical records.
  • Inclusion criteria: diagnosis of head and neck dermatitis and treatment with oral azole antifungals.
  • Study period: 2 years, involving 24 patients.

Main Results:

  • 17 out of 24 patients (over two-thirds) showed a positive response to azole antifungal treatment.
  • Patients' characteristic flares often began in adolescence or early adulthood.
  • Average treatment duration was 8 months, with a 10-month follow-up period.

Conclusions:

  • Systemic azole antifungals, including itraconazole, are effective for treating head and neck atopic dermatitis in adults.
  • The study highlights a significant treatment response in a majority of patients.
  • Limitations include the retrospective nature and small sample size from a single institution.
Keywords:
Malasseziaatopic dermatitiscontact dermatitiseczemafluconazolehead and neck dermatitisitraconazoleketoconazoleoccupational dermatitisseborrheic dermatitis

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