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Approach to patients with unexplained multimorbidity with sensitivities
Stephen J Genuis1, Marko G Tymchak2
1Clinical Professor in the Faculty of Medicine and Dentistry at the University of Alberta in Edmonton. sgenuis@shaw.ca.
Canadian Family Physician Medecin De Famille Canadien
|June 14, 2014
Summary
Unexplained multimorbidity with sensitivities is often linked to environmental toxicant bioaccumulation. Managing this sensitivity-related illness involves identifying and removing triggers and toxicants.
Area of Science:
- Environmental Health
- Toxicology
- Immunology
Background:
- Multimorbidity with sensitivities presents a growing challenge in primary care.
- Patients exhibit multisystem complaints, fatigue, and sensitivities without clear causes.
- Sensitivity-related illness is an immune-mediated disorder with diverse symptoms.
Purpose of the Study:
- To investigate the causes of unexplained multimorbidity with sensitivities.
- To outline management strategies for patients with this condition.
Main Methods:
- Literature review encompassing MEDLINE (PubMed), books, journals, and government publications.
- Analysis of scientific and medical literature on toxicology, allergy, and environmental health.
Main Results:
- Sensitivity-related illness is frequently associated with environmental exposures and toxicant bioaccumulation.
- This condition often underlies unexplained multimorbidity and sensitivities in clinical presentations.
- Lack of definitive laboratory findings complicates diagnosis and treatment.
Conclusions:
- Toxicant exposure and bioaccumulation are common triggers for sensitivity-related illness.
- Clinical management focuses on trigger avoidance, biochemical optimization, and toxicant elimination.
- Addressing environmental factors and internal toxicant burden can improve patient health outcomes.
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