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Updated: Apr 28, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Acute pancreatitis complicating severe dengue.
Vishakha Jain1, Op Gupta1, Tarun Rao1
1Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India.
Severe dengue, a life-threatening viral infection, can rarely cause acute pancreatitis. Early recognition of this severe dengue complication is crucial for effective patient management and improved outcomes.
Area of Science:
- Infectious Diseases
- Gastroenterology
- Critical Care Medicine
Background:
- Dengue is a prevalent arthropod-borne viral illness in tropical and subtropical regions.
- Severe dengue poses a significant threat to life, with diverse clinical manifestations.
- Atypical presentations of dengue are increasingly recognized, necessitating broader clinical awareness.
Observation:
- A case study of a 27-year-old male with severe dengue presenting in decompensated shock.
- The patient exhibited abdominal pain indicative of acute pancreatitis alongside severe dengue symptoms.
- This presentation highlights a rare and fatal complication of dengue viral infection.
Findings:
- The study documents a rare instance of acute pancreatitis as a complication of severe dengue.
- The exact pathogenesis linking dengue to acute pancreatitis remains under investigation, with several mechanisms proposed.
- Timely diagnosis and management are critical for patients presenting with this dual condition.
Implications:
- Increased clinical awareness of acute pancreatitis in dengue patients is essential for prompt diagnosis.
- Understanding the pathophysiology may lead to targeted therapies for dengue-associated pancreatitis.
- This case underscores the importance of considering atypical presentations in severe dengue management.
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