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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation01:35

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation01:25

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Alzheimer Disease ll: Pathophysiology01:23

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
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Related Experiment Video

Updated: Apr 28, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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Longevity pathways and memory aging.

Ilias Gkikas1, Dionysia Petratou1, Nektarios Tavernarakis2

  • 1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion Crete, Greece.

Frontiers in Genetics
|June 14, 2014
PubMed
Summary
This summary is machine-generated.

Aging impairs brain functions like learning and memory. This review explores conserved molecular pathways in aging and memory, crucial for developing treatments for age-related memory loss.

Keywords:
Alzheimer’s diseaseautophagydietary restrictioninsulin/IGF-1 signalinglearningmitochondrianeurodegeneration, TOR signaling

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Gerontology

Background:

  • Aging is linked to cellular and organ pathologies, notably cognitive decline.
  • Age-related memory impairment significantly impacts quality of life and adaptive behaviors.
  • Understanding molecular mechanisms is key to developing therapies for memory loss.

Purpose of the Study:

  • To review conserved molecular pathways involved in both aging and memory.
  • To highlight progress in understanding the link between aging and memory formation/consolidation.

Main Methods:

  • Survey of recent scientific literature.
  • Focus on conserved molecular pathways identified in invertebrate models.

Main Results:

  • Identified conserved molecular pathways implicated in aging and memory.
  • Highlighted the role of these pathways in memory formation and consolidation.

Conclusions:

  • Molecular pathways conserved across species are vital for understanding age-related memory impairment.
  • Further research into these pathways can guide the development of therapeutic strategies for cognitive decline.