Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

793
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
793
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

699
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
699
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.2K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.2K
Bipolar Disorder01:30

Bipolar Disorder

1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

1.0K
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
1.0K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.3K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long lifetime of bialkali photocathodes operating in high gradient superconducting radio frequency gun.

Scientific reports·2021
Same author

Expression of p27 and p16 and their clinical significance in gastric cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2020
Same author

High-Brightness Continuous-Wave Electron Beams from Superconducting Radio-Frequency Photoemission Gun.

Physical review letters·2020
Same author

Experimental Demonstration of Hadron Beam Cooling Using Radio-Frequency Accelerated Electron Bunches.

Physical review letters·2020
Same author

Spatial evaluation of prevalence, pattern and predictors of cervical cancer screening in India.

Public health·2019
Same author

Carcinoma of the Tongue in Renal Transplant Recipients: An Unusual Spectrum of <i>De novo</i> Malignancy at a Tertiary Care Center in India Over a Period of 26 Years.

Indian journal of nephrology·2018

Related Experiment Video

Updated: Apr 28, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

1.8K

Olanzapine-induced mania.

G Narayan1, A Puranik

  • 1Priority House, Maidstone, Kent, UK.

International Journal of Psychiatry in Clinical Practice
|June 14, 2014
PubMed
Summary

Olanzapine can induce severe manic symptoms in elderly patients with delusional disorder. Discontinuation of olanzapine led to the resolution of these manic symptoms.

Area of Science:

  • Geriatric Psychiatry
  • Pharmacovigilance
  • Clinical Case Reports

Background:

  • Delusional disorder is a psychiatric condition characterized by persistent delusions.
  • Antipsychotic medications are commonly used in the management of delusional disorder.
  • Olanzapine is an atypical antipsychotic with a known side effect profile.

Purpose of the Study:

  • To report a case of olanzapine-induced mania in an elderly patient.
  • To highlight the potential for atypical antipsychotics to cause manic symptoms.
  • To discuss the management and resolution of drug-induced mania.

Main Methods:

  • Case report of an 85-year-old female with delusional disorder.
  • Review of past treatments including trifluoperazine and risperidone.
Keywords:
Olanzapine Manic Symptoms Delusional Disorder

More Related Videos

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.7K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

14.2K

Related Experiment Videos

Last Updated: Apr 28, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

1.8K
Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.7K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

14.2K
  • Clinical observation of manic symptoms following olanzapine initiation.
  • Assessment of symptom resolution after olanzapine discontinuation.

    • Main Results:

    • The patient developed severe manic symptoms requiring hospitalization after starting olanzapine.
    • Manic symptoms significantly improved within two weeks of discontinuing olanzapine.
    • Low-dose haloperidol was used as needed for residual symptoms.

    Conclusions:

    • Olanzapine may precipitate manic symptoms in elderly individuals with pre-existing psychiatric conditions.
    • Careful monitoring for emergent manic symptoms is crucial when prescribing olanzapine, especially in the elderly.
    • Discontinuation of the offending agent is an effective strategy for managing drug-induced mania.