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Tolerance: one transplant for life.

Tatsuo Kawai1, Joseph Leventhal, Joren C Madsen

  • 11 Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Department of Medicine, Northwestern University School of Medicine, Chicago, IL. 3 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 4 Department of Medicine, Stanford University School of Medicine, Palo Alto, CA. 5 Immune Tolerance Network, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 6 Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom. 7 Address correspondence to: Laurence A. Turka, M.D., Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, 149 13th St, Room 5101, Boston, MA 02129.

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Summary
This summary is machine-generated.

Establishing tolerance induction protocols as standard care requires a registry, standardized sample handling and assays, pediatric inclusion, and payer engagement. Future workshops will track progress and identify further steps.

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Area of Science:

  • Immunology
  • Transplantation Medicine

Background:

  • The Transplantation Society convened a workshop to define requirements for making tolerance induction protocols a standard of care within the next decade.
  • Discussions focused on overcoming barriers to widespread adoption of these advanced immunosuppression strategies.

Framework:

  • Establish a comprehensive registry for tracking patient outcomes in tolerance induction trials.
  • Develop standardized protocols for biological sample collection, storage, and analysis.
  • Standardize biomarkers and assays to ensure consistent and reliable measurement of tolerance induction efficacy.

Implementation:

  • Incorporate pediatric patients (12 years and older) into clinical protocols once validated in adult populations.
  • Form a dedicated task force to initiate discussions with third-party payers regarding funding mechanisms for tolerance trials.

Implications:

  • These recommendations aim to facilitate the transition of tolerance induction protocols from experimental to routine clinical practice.
  • Future workshops will monitor the implementation of these recommendations and identify additional community-driven actions.