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Updated: Apr 28, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
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Focus on social functioning in depression.

R Hirschfeld1, M Keller, M Bourgeois

  • 1Department of Psychiatry and Behavioral Sciences, University of Texas, USA.

International Journal of Psychiatry in Clinical Practice
|June 14, 2014
PubMed
Summary
This summary is machine-generated.

Depression significantly impacts social functioning, often inadequately treated. Antidepressants may improve social impairment, but more research comparing drug classes is needed for treatment guidelines.

Keywords:
antidepressantsdepressionglobal disease burdensocial functioning

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Public Health

Background:

  • Depressive disorders are a major global health issue, predicted to cause 15% of the global disease burden by 2020.
  • Depression is often underdiagnosed and undertreated, with many affected individuals not seeking or receiving adequate care.
  • Impaired social functioning is a significant consequence of depression, affecting individuals and their families, yet it's not a primary treatment focus.

Purpose of the Study:

  • To highlight the importance of treating impaired social functioning in depression.
  • To review existing evidence on antidepressants for social impairment in depression.
  • To stimulate discussion for developing future treatment guidelines.

Main Methods:

  • Review of early studies on antidepressant efficacy for social functioning in depression.
  • Identification of a gap in comparative studies across different antidepressant classes.
  • Discussion of key issues for establishing treatment guidelines.

Main Results:

  • Antidepressants show potential in improving core depressive symptoms and social functioning.
  • Limited direct comparative data exists for different antidepressant classes regarding social functioning.
  • Depression causes greater functional impairment than other chronic conditions like diabetes or hypertension.

Conclusions:

  • Addressing impaired social functioning is crucial for comprehensive depression treatment.
  • Further research, particularly comparative studies of antidepressants, is needed.
  • The paper aims to inform the development of evidence-based treatment guidelines for social functioning in depression.