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A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer
Yihong Wang1, Zheng Miao, Gang Ren
1Department of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, P. R. China.
Chemical Communications (Cambridge, England)
|June 14, 2014
Abstract:
An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.
