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Updated: Apr 28, 2026

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
[Clinical presentations of pediatric anti-N-methyl-D-aspartate receptor encephalitis]
1Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. jiangyw@263.net.
Insights
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common autoimmune condition in children. This review details the typical and atypical clinical presentations of pediatric NMDAR encephalitis.
Area of Science:
- Neurology
- Immunology
- Pediatrics
Context:
- Autoimmune encephalitis is a growing concern in pediatric neurology.
- Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a prominent form, affecting children.
- Understanding its varied clinical manifestations is crucial for timely diagnosis.
Purpose:
- To review the clinical presentations of anti-NMDAR encephalitis in children.
- To differentiate between typical and atypical cases.
- To highlight key characteristics of pediatric anti-NMDAR encephalitis.
Summary:
- This review examines the clinical features of anti-NMDAR encephalitis in pediatric populations.
- It covers both classic and unusual presentations, aiding in recognition.
- Key characteristics specific to childhood cases are discussed.
Impact:
- Improved diagnostic accuracy for pediatric autoimmune encephalitis.
- Facilitation of earlier treatment initiation for affected children.
- Enhanced understanding of NMDAR encephalitis's impact on pediatric health.
Abstract:
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is one of the most common autoimmune encephalitis in children with characterized clinical features. Here we review clinical presentations of typical and atypical anti-NMDAR encephalitis and characteristics of clinical presentations of pediatric anti-NMDAR encephalitis.
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