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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

White matter changes with age utilizing quantitative diffusion MRI.

Laurie M Baker¹, David H Laidlaw², Thomas E Conturo²

¹From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN. lauriebaker@umsl.edu.

|June 15, 2014

Summary

This summary is machine-generated.

Older age is linked to shorter cerebral white matter fiber bundle lengths (FBLs) in specific brain tracts. This inverse relationship suggests potential changes in white matter integrity with aging.

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Area of Science:

Neuroimaging
Gerontology
Neuroscience

Background:

Aging is associated with structural changes in the brain.
White matter integrity is crucial for cognitive function.
Quantified diffusion MRI offers insights into white matter microstructure.

Purpose of the Study:

To investigate the relationship between aging and white matter fiber bundle lengths (FBLs).
To examine specific white matter tracts in healthy older adults.
To utilize quantified diffusion MRI for precise measurements.

Main Methods:

Diffusion tensor imaging (DTI) was performed on 63 healthy adults over 50 years old.
Tractography was used to derive cerebral white matter fiber bundles from DTI data.
Mean fiber bundle lengths (FBLs) were quantified for specific tracts.

Main Results:

A significant inverse relationship was found between age and FBLs.
Specifically, shorter FBLs in the anterior thalamic radiation were observed with each year increase over 50.
This suggests age-related changes in white matter microstructure.

Conclusions:

Quantified diffusion MRI revealed a significant inverse relationship between age and FBLs in healthy older individuals.
Age-related shortening of white matter fiber bundles was observed in specific tracts.
Longitudinal studies are recommended to track white matter integrity changes across the lifespan.