Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep tree roots at risk of accelerating groundwater pollution beneath clay-rich aquitards.

Nature communications·2026
Same author

Engineering CoCa diatomic oxygen reduction electrocatalysts for high-performance zinc-air battery.

Journal of colloid and interface science·2026
Same author

Order-shifting temporal phase unwrapping using uneven duty gray-code for high-accurate and high-efficient 3D measurement.

Optics letters·2026
Same author

Creating Concentration-Insensitive TADF Luminogens With Spiro-Fused Xanthone Acceptors for Highly Efficient OLEDs.

Angewandte Chemie (International ed. in English)·2026
Same author

Chiral plasmonic rhombic dodecahedral gold nanoparticles for photodynamic antibacterial films in food preservation.

Food chemistry·2026
Same author

Hepatitis B core antigen-based trivalent VLP vaccine against porcine viral diarrhea.

Vaccine·2026

Related Experiment Video

Updated: Apr 28, 2026

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.4K

Solid self-microemulsifying dispersible tablets of celastrol: formulation development, charaterization and

Xiaole Qi1, Jiayi Qin1, Ning Ma1

  • 1Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, PR China.

International Journal of Pharmaceutics
|June 15, 2014
PubMed
Summary

Developing solid self-microemulsifying dispersible tablets for celastrol significantly enhances its oral bioavailability. These tablets offer a promising delivery system for poorly water-soluble drugs like celastrol.

Keywords:
CelastrolDispersible tabletsOral bioavailabilitySolid self-microemulsifying system (S-SMEDDS)

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.3K
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.0K

Related Experiment Videos

Last Updated: Apr 28, 2026

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.4K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.3K
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.0K

Area of Science:

  • Pharmaceutics
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Celastrol, a poorly water-soluble terpene, faces challenges in oral administration due to low bioavailability.
  • Self-microemulsifying drug delivery systems (SMEDDS) offer a strategy to improve the solubility and absorption of such compounds.

Purpose of the Study:

  • To develop solid self-microemulsifying dispersible tablets of celastrol.
  • To enhance the dissolution and oral bioavailability of celastrol using SMEDDS technology.

Main Methods:

  • Screening and optimization of liquid celastrol SMEDDS using solubility tests, droplet size analysis, and ternary phase diagrams.
  • Preparation of dispersible tablets by adsorbing optimized SMEDDS onto microcrystalline cellulose via wet granulation.
  • In vitro dispersion and particle size analysis.
  • In vivo pharmacokinetic studies in rats.

Main Results:

  • Optimized celastrol-SMEDDS dispersible tablets dispersed within 3 minutes with an average particle size of 25.32 ± 3.26 nm.
  • In vivo studies demonstrated significantly enhanced relative bioavailability for both celastrol SMEDDS (569 ± 7.07%) and SMEDDS dispersible tablets (558 ± 6.77%) compared to a conventional suspension.
  • No significant difference in bioavailability was observed between the liquid SMEDDS and the dispersible tablet formulations.

Conclusions:

  • Celastrol-loaded SMEDDS dispersible tablets are effectively prepared using microcrystalline cellulose as an adsorbent.
  • This formulation demonstrates excellent in vitro dispersion characteristics and significantly improves the oral bioavailability of celastrol.
  • SMEDDS dispersible tablets represent a viable and effective oral delivery strategy for poorly water-soluble terpene drugs.