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Updated: Apr 28, 2026
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
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Hydrogen sulfide and nitric oxide interactions in inflammation
Maria Letizia Lo Faro1, Bridget Fox1, Jacqueline L Whatmore1
1University of Exeter Medical School, Saint Luke's Campus, Heavitree Road, EX1 2LU Exeter, UK.
Nitric Oxide : Biology and Chemistry
|June 15, 2014
Summary
Nitric oxide (NO) and hydrogen sulfide (H2S) are key gaseous transmitters. Their interactions significantly influence inflammatory processes, highlighting the importance of their cross-talk in biological systems.
Area of Science:
- Physiology
- Biochemistry
- Immunology
Background:
- Nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO) are vital gaseous transmitters.
- These molecules share properties like membrane permeability and endogenous production.
- They exhibit diverse physiological roles, including vasodilation and tissue protection.
Purpose of the Study:
- To review the roles of NO and H2S in inflammation.
- To explore the evidence for cross-talk between NO and H2S in inflammatory pathways.
Main Methods:
- Literature review of existing research on NO, H2S, and inflammation.
- Analysis of studies investigating the interactions between these gaseous molecules.
Main Results:
- NO and H2S have complex, dual roles in inflammation (both pro- and anti-inflammatory).
- Evidence suggests significant cross-talk between NO and H2S modulates inflammatory responses.
Conclusions:
- The interplay between NO and H2S is crucial for understanding and regulating inflammation.
- Further research into NO-H2S interactions may reveal novel therapeutic targets for inflammatory diseases.
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