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Seroepidemiology and phylogenetic characterisation of measles virus in Ireland, 2004-2013

Bernadette O' Riordan1, Michael J Carr1, Jeff Connell1

  • 1National Virus Reference Laboratory, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|June 16, 2014
PubMed
Abstract

Insights

Ireland experienced measles outbreaks with increasing cases in individuals over 10 years old. Genotyping revealed indigenous and imported measles virus strains, highlighting the need to update vaccination strategies for susceptible populations.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Ireland is recognized as an area with high measles incidence.
  • A strategic plan by the World Health Organization aims for measles elimination in Europe by 2015.

Purpose of the Study:

  • To retrospectively analyze measles outbreaks in Ireland.
  • To characterize the genetic diversity of measles virus genotypes circulating within the country.
  • To differentiate between indigenous and imported measles strains.

Main Methods:

  • Confirmed 704 cases of acute measles infection using measles-specific IgM in sera and oral fluids.
  • Genotyped 116 measles-positive samples.
  • Performed sequence analysis and phylogenetic characterization of viral strains.

Main Results:

  • Identified three measles outbreaks in 2004, 2009/2010, and 2011.
  • Observed a significant increase in measles cases among individuals older than 10 years across outbreaks.
  • Phylogenetic analysis confirmed indigenous transmission of genotype D4 and importation events involving genotype D8.

Conclusions:

  • Comprehensive genetic analysis of measles genotypes in Ireland was performed.
  • An increase in measles cases among those over 10 years old was noted, indicating potential gaps in vaccination coverage.
  • Findings are crucial for informing targeted vaccination strategies to address susceptible populations and prevent future outbreaks.
Keywords:
IrelandMeaslesPhylogeneticsSeroepidemiology

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