Frequencies of Duffy blood group alleles in Northern Pakistani donors

Find the allele frequencies of Duffy blood group antigens in donor population from northern Pakistan.

Cross sectional study.

Armed Forces Institute of Transfusion (AFIT), Rawalpindi in year 2012.

A total of 1000 healthy, adult blood donors were included in the study. Blood samples were collected in ethylenediamine tetra aceticacid (EDTA) tube and then tested with anti sera Fy(a) and Fy(b) by the tube method.

The allele frequencies of Duffy blood group antigens were calculated. The most common phenotype was Fy(a+b+) which was present in 552 (55.2%) donors followed by the Fy(a+b-) phenotype in 228 (22.8%) donors, while 178 (17.8%) were Fy(a-b+) and the least prevalent phenotype was Fy(a-b-) which was present in 42 (4.2%) of donors.

The majority of our population is heterozygous for Duffy antigens a and b.