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Light-chain nephropathy. A report of 2 cases
1Department of Anatomical Pathology, University of Natal and King Edward VIII Hospital, Durban.
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|February 18, 1989
Abstract:
Two cases of renal impairment caused by the deposition of monoclonal immunoglobulin light-chain determinants in the glomerular mesangium and basement membranes as well as in the tubular basement membranes of the kidney are described (light-chain nephropathy). Both cases were associated with myeloma. Examinations by light microscopy, immunohistochemistry and electron microscopy are also described. Differential diagnoses on light microscopy include diabetic glomerulosclerosis (Kimmelstiel-Wilson lesions), amyloidosis and mesangiocapillary glomerulonephritis type 1.