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Prophylactic eculizumab for kidney transplantation in a child with atypical hemolytic uremic syndrome due to

Daniel Ranch1, Barrett Crowther, Mazen Arar

  • 1Department of Pediatrics, University of Texas Health Science Center, San Antonio, TX, USA.

Pediatric Transplantation
|June 17, 2014
PubMed

Insights

A child with atypical hemolytic uremic syndrome (aHUS) underwent successful kidney transplant. Despite initial post-operative aHUS exacerbation, additional eculizumab doses controlled the disease and maintained graft function, highlighting the need for optimized treatment protocols.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Rare Diseases

Background:

  • Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening condition characterized by thrombotic microangiopathy.
  • Complement factor H mutations are a common genetic cause of aHUS.
  • Kidney transplantation is a potential treatment for end-stage renal disease in aHUS patients, but carries a risk of disease recurrence.

Keywords:
atypical hemolytic uremic syndromecomplement factor Heculizumabpediatric kidney transplantation

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