Pattern of acute poisonings in children below 15 years--a study from Mangalore, South India

Pradhum Ram1, Tanuj Kanchan2, B Unnikrishnan3

  • 1Kasturba Medical College, Mangalore, Manipal University, India.

Insights

Acute childhood poisoning is a significant pediatric emergency. This study found kerosene and organophosphates were common causes, with varied patterns across age groups, highlighting the need for tailored prevention strategies.

Area of Science:

  • Pediatrics
  • Toxicology
  • Public Health

Background:

  • Acute poisoning in children is a widespread pediatric emergency requiring urgent medical attention.
  • Understanding regional patterns of childhood poisoning is crucial for effective public health interventions.

Purpose of the Study:

  • To investigate the epidemiological patterns and outcomes of acute poisoning in children under 15 years.
  • To characterize the problem of acute pediatric poisoning in different age groups within a South Indian tertiary care setting.

Main Methods:

  • Retrospective review of medical records for poisoning cases admitted between 2010 and 2011.
  • Data collection included sociodemographic information and clinical profiles of pediatric poisoning patients.

Main Results:

  • 81 children under 15 years experienced acute poisoning; kerosene (28.4%) and organophosphates (19.8%) were the most frequent agents.
  • The highest incidence was in children under 5 years, with male predominance in this group and female predominance in the 10-15 year age group.
  • Mortality was 7.4%, with most children recovering (84.0%); 8.6% left against medical advice.

Conclusions:

  • Agrochemicals and hydrocarbons are primary agents in pediatric poisoning, with age-specific variations in causes.
  • Tailored preventive strategies are essential, considering the differing causes of poisoning across various pediatric age groups.

Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.4K
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
271
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
2.0K
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
116
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
1.1K
Antidotes01:17

Antidotes

Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
1.4K