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Updated: Apr 28, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
Masahiko Kanamori1, Taketoshi Yasuda2, Shigeharu Nogami2
1Department of Human Science, University of Toyama, Toyama City, Toyama 930-0194, Japan ; Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.
Abstract:
Pleomorphic leiomyosarcoma (P-LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P-LMS that arose in the axillary region of a 31-year-old male. The results of array-based comparative genomic hybridization for the primary tumor showed DNA copy number alteration (DCNA) gains of 8ptel, 17ptel and 17q11.2 and losses of 2ptel, 7ptel, 7qtel, 10p15, 12p12-13.1, 13q14.2-14.3, 15q25-26 and Yq11. However, a metastatic lesion showed cytogenetic data different from the primary tumor DCNAs, with only the locus of 17ptel (282M15/SP6) in common between them. These observations add to the spectrum of DCNAs that have been reported in previous cases of LMS and provide novel cytogenetic data.
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