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Metabolic bone disease of prematurity: report of four cases

Gül Yeşiltepe Mutlu1, Heves Kırmızıbekmez, Elif Ozsu

  • 1eynep Kamil Gynecologic and Pediatric Training and Research Hospital, Department of Pediatric Endocrinology, İstanbul, Turkey. E-ma-il: gulyesiltepe@gmail.com.

Journal of Clinical Research in Pediatric Endocrinology
|June 17, 2014
PubMed

Insights

Osteopenia of prematurity is common in very low birth weight (VLBW) infants. Adequate enteral calcium, phosphorus, and vitamin D are crucial after neonatal intensive care unit (NICU) discharge to prevent bone disease.

Area of Science:

  • Neonatology
  • Pediatric Endocrinology
  • Nutritional Science

Background:

  • Improved survival rates for very low birth weight (VLBW) infants have increased the incidence of osteopenia of prematurity.
  • Neonatal osteopenia risk is inversely related to gestational age and birth weight.

Observation:

  • Presents four cases of preterm osteopenia with varied clinical and laboratory findings.
  • Infants were referred to pediatric endocrinology outpatient clinics.
  • Discusses the post-neonatal intensive care unit (NICU) course concerning bone disease.

Findings:

  • Highlights the critical role of enteral calcium, phosphorus, and vitamin D supplementation.
  • Emphasizes the need for adequate nutrient doses post-NICU discharge.
  • Identifies risk factors for metabolic bone disease in VLBW infants.

Implications:

  • Stresses the importance of tailored nutritional support for VLBW infants at risk.
  • Informs clinical practice regarding the long-term bone health management of preterm infants.
  • Underscores the need for vigilant monitoring and intervention for metabolic bone disease in vulnerable neonates.

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