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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Application of Peak Nasal Inspiratory Flow reference values in the treatment of allergic rhinitis

S de Souza Campos Fernandes, C Ribeiro de Andrade, C da Cunha Ibiapina

    Rhinology
    |June 17, 2014
    PubMed

    Insights

    Peak Nasal Inspiratory Flow (PNIF) curves effectively monitor children with allergic rhinitis. Intranasal corticosteroid treatment significantly improved PNIF percentages compared to placebo, showing PNIF

    Area of Science:

    • Pediatric Allergy and Immunology
    • Respiratory Medicine
    • Clinical Research

    Background:

    • Allergic rhinitis (AR) is a common condition in children, impacting their quality of life.
    • Effective monitoring of AR treatment is crucial for optimal patient outcomes.
    • Peak Nasal Inspiratory Flow (PNIF) is a physiological measure that can reflect nasal obstruction.

    Purpose of the Study:

    • To evaluate the clinical utility of Peak Nasal Inspiratory Flow (PNIF) curves for monitoring treatment response in children with allergic rhinitis.
    • To compare the effectiveness of intranasal corticosteroid spray versus saline solution in improving PNIF and clinical symptoms.

    Main Methods:

    • A prospective study involving 40 children diagnosed with allergic rhinitis.
    • Participants were randomized to receive either intranasal corticosteroid spray or physiological saline solution for 10 weeks.
    • Clinical scores and PNIF percentages (relative to reference curves) were assessed throughout the study period, with a washout at week 8.

    Main Results:

    • A statistically significant influence of treatment group, time, and their interaction was observed on PNIF percentages.
    • Children treated with intranasal corticosteroids demonstrated significantly higher mean PNIF percentages compared to the placebo group.
    • Clinical score improvements were also significantly greater in the corticosteroid treatment group.

    Conclusions:

    • Peak Nasal Inspiratory Flow (PNIF) curves are applicable and effective in the follow-up of children undergoing treatment for allergic rhinitis.
    • Intranasal corticosteroid therapy leads to significant improvements in nasal airflow, as measured by PNIF, in pediatric patients with AR.
    Abstract

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