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[An immunologic method of producing antigens for the treatment and prevention of leishmaniasis]

I Vouldoukis1, L Monjour

  • 1Laboratoire de Parasitologie expérimentale et I.N.S.E.R.M. U n. 313, Faculté de Médecine Pitié-Salpétrière, Paris.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|January 1, 1989
PubMed

Antigens isolated from lysates of L. infantum promastigotes by electroelution from polyacrylamide gels and by gel filtration, have already been proven to induce anti-Leishmania protective immunity in BALB/c mice when injected subcutaneously. At the present time, five preparations including either Leishmania antigens or anti-idiotypic reagents as vaccines can be considered as candidates for immunoprophylaxis in natural hosts of Leishmania parasites. We present a new method for producing Leishmania antigenic preparations which is of considerable interest, since it can be proposed for immunotherapy and prevention of other parasitic, bacterial, viral and perhaps, retroviral diseases.

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