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[The study of hormonal status in children with gastroesophageal reflux disease]

N V Butorina, A M Zaprudnov, Ia M Vakhrushev

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |June 18, 2014
    PubMed

    Insights

    Hormonal imbalances, including somatostatin, gastrin, insulin, and cortisol, play a key role in the development of pediatric gastroesophageal reflux disease (GERD). These hormonal changes impact stomach motility and protective mechanisms.

    Area of Science:

    • Pediatric Gastroenterology
    • Endocrinology
    • Gastrointestinal Pathophysiology

    Context:

    • Gastroesophageal reflux disease (GERD) is a common condition in children.
    • The role of hormonal dysregulation in the pathogenesis of pediatric GERD is not fully understood.
    • This study investigates specific hormones and their impact on GERD in pediatric patients.

    Purpose:

    • To examine the levels of somatostatin, gastrin, insulin, and cortisol in children diagnosed with GERD.
    • To elucidate the relationship between these hormones and the pathogenesis of pediatric GERD.
    • To assess the influence of hormonal imbalances on stomach motor function in affected children.

    Summary:

    • A study of 40 children (ages 9-17) with GERD revealed age-dependent variations in somatostatin and gastrin concentrations.
    • Imbalances in somatostatin and gastrin were associated with impaired stomach motility.
    • Elevated insulin and cortisol levels were observed in children with GERD, suggesting altered adaptive and catabolic processes.

    Impact:

    • Findings highlight the critical involvement of hormonal factors in the development of GERD in children.
    • This research provides insights into potential therapeutic targets for managing pediatric GERD.
    • Understanding hormonal influences can lead to improved diagnostic and treatment strategies for pediatric GERD.
    Abstract

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